The theory suggests that dietary calcium increases lipolysis and preserves thermogenesis, thereby accelerating weight loss. As noted, high intracellular calcium levels promote lipogenesis and inhibit lipolysis. ( 3), is that low calcium intake stimulates dihydroxy vitamin D and PTH and that, in turn, these calcitropic circulating substances stimulate adipocyte calcium uptake. These population observations are supported by retrospective analysis of a number of data sets that included calcium intake information and, in some cases, longitudinal administration of calcium as part of an osteoporosis trial ( 4).īoth the mechanism and magnitude of the calcium-body weight effect remain uncertain. National Health and Nutrition Examination Surveys I and III both provide cross-sectional evidence for an inverse association between calcium intake and body mass index (BMI kilograms per square meter) ( 2, 3). Within adipocytes, intracellular calcium levels alter the balance between lipid synthesis and breakdown, favoring lipogenesis when cytosolic calcium levels are high ( 1). New evidence and review of earlier studies supports the view that calcium also plays a role in adipocyte lipid kinetics at the cellular level and in moderating fatness at the population level. Nevertheless, the magnitude and direction of the differences for group means are consistent with a hypothesized small effect.Ĭalcium is generally considered a key element for maintaining bone mineral homeostasis. Calcium supplementation did not significantly affect amount of weight or fat lost by women counseled to follow a moderately restricted diet for 25 wk. Analysis as separate trials also found no significant differences between the placebo and the calcium groups. Ca –5.5 ± 0.6 kg), and no significant interactions of calcium supplementation with menopausal/diet status. There were no significant differences in body weight or fat mass change between the placebo and the calcium-supplemented groups in the pooled analysis (adjusted mean ± SE body weight, placebo –6.2 ± 0.7 vs. The primary outcome measures were change in body weight and fat mass adjusted for baseline values. Data were combined from three separate 25-wk randomized, double blind, placebo-controlled trials of 1000 mg/d calcium supplementation in 100 premenopausal and postmenopausal women. Our aim was to determine whether calcium supplementation during a weight loss intervention affects body fat or weight loss. Data suggest that a diet deficient in calcium is associated with higher body weight and that augmenting calcium intake may reduce weight and fat gain or enhance loss.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |